The Thompson Lab

Publications

Expanding the space of protein geometries by computational design of ​de novo fold families

Pan X, Thompson M, Zhang Y, Liu L, Fraser JS, Kelly MJS, Kortemme T. (2020) Science.


An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj VV, Hoppe N, Boone M, Billesboelle C, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chi US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, Garcia-Sastre A, Ott M, Vignuzzi M, Quantitative Biosciences Institute (QBI) Coronavirus Research Group Structural Biology Consortium, Walter P, Manglick A. (2020) Submitted - Preprint on Biorxiv.


Advances in methods for atomic resolution macromolecular structure determination

Thompson MC, Yeates TO, Rodriguez JA. (2020) F1000Res.

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Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst

Broom A, Rakotoharisoa RV, Thompson MC, Zarifi N, Nguyen E, Mukhametzhanov N, Liu L, Fraser JS, Chica RA. (2020) Submitted - Preprint on BioRxiv.

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Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals

Wolff AM, Young ID, Sierra RG, Brewster AS, Martynowycz MW, Nango E, Sugahara M, Nakane T, Ito K, Aquila A, Bhowmick A, Biel JT, Carbajo S, Cohen AE, Cortez S, Gonzalez A, Hino T, Im D, Koralek JD, Kubo M, Lazarou TS, Nomura T, Owada S, Samelson A, Tanaka R, Tanaka T, Thompson EM, van den Bedem H, Woldeyes RA, Yumoto F, Zhao W, Tono K, Boutet S, Iwata S, Gonen T, Sauter NK, Fraser JS, Thompson MC. (2020) IUCrJ.


Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis

Dasgupta M, Budday D, Oliveira SHP, Madzelan P, Marchany-Rivera D, Seravalli J, Hayes B, Sierra RG, Boutet S, Hunter MS, Alonso-Mori R, Batyuk A, Wierman J, Lyubimov A, Brewster AS, Sauter NK, Applegate GA, Tiwari VK, Berkowitz DB, Thompson MC, Cohen AE, Fraser JS, Wall ME, van den Bedem H, Wilson MA. (2019) PNAS.


Computational design of a modular protein sense/response system

Glasgow AA, Huang Y, Mandell DJ, Thompson M, Ritterson R, Loshbaugh AL, Pellegrino J, Krivacic C, Pache RA, Barlow KA, Ollikainen N, Jeon D, Kelly MJS, Fraser JS, Kortemme T. (2019) Science.


Temperature-Jump Solution X-ray Scattering Reveals Distinct Motions in a Dynamic Enzyme

Thompson MC, Barad BA, Wolff AM, Cho HS, Schotte F, Schwarz DMC, Anfinrud P, Fraser JS. (2019) Nature Chemistry.


Microfocus diffraction from different regions of a protein crystal: structural variations and unit-cell polymorphism

Thompson MC, Cascio D, Yeates TO. (2018) Acta Cryst D.

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Allosteric Inhibitors, Crystallography and Comparative Analysis Reveal Network of Coordinated Movement Across Human Herpesvirus Proteases

Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS. (2017) JACS.

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Identifying and Overcoming Crystal Pathologies: Disorder and Twinning

Thompson MC. (2017) Protein Crystallography: Methods and Protocols.

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Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin

Biel JT, Thompson MC, Cunningham CN, Corn JE, Fraser JS. (2017) Structure.


Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein

Jorda J, Leibly DJ, Thompson MC, Yeates TO. (2016) Chemical Communications.

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An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein

Thompson MC, Cascio D, Leibly DJ, Yeates TO. (2015) Protein Science.

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Mapping the Conformational Landscape of a Dynamic Enzyme by Multitemperature and XFEL Crystallography

Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS. (2015) eLife.


Structure of a bacterial microcompartment shell protein bound to a cobalamin cofactor

Thompson MC, Crowley CS, Kopstein J, Bobik TA, Yeates TO. (2014) Acta Cryst F.

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Identification of a unique Fe-S cluster binding site in a glycyl-radical type microcompartment shell protein

Thompson MC, Wheatley NM, Jorda J, Sawaya MR, Gidaniyan SD, Ahmed H, Yang Z, McCarty KN, Whitelegge JP, Yeates TO. (2014) J. Mol. Bio.

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A challenging interpretation of a hexagonally layered protein structure

Thompson MC, Yeates TO. (2013) Acta Cryst D.

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The protein shells of bacterial microcompartment organelles

Yeates TO, Thompson MC, Bobik TA. (2011) Curr. Opin. Struct. Bio..

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